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Author contributions HH: Conceptualization, Methodology, Writingoriginal draft, Writingreview and editing

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Small populations of open conformations exist as well and can smoothly accommodate the ligand.61 GLP-1R activation triggers Gs-protein coupling, elevating cAMP, modulating calcium mobilization, and inducing -arrestin recruitment.62 Different ligands lead to different interaction patterns with the receptor, generating various effects